NCT01950039

Metabolic Effects of Betaine Supplementation

Bedside to Bench and Back: Cardiometabolic Effects of Betaine Supplementation

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 28 (actual)
• Sponsor: Joslin Diabetes Center · Academic / Other
• Sex: All
• Age: 21 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Betaine is important in cellular metabolic pathways. Few epidemiologic studies link betaine levels to diabetes and cardiovascular disease. Small human studies suggest benefit for non-alcoholic liver disease. In this study we will determine if administration of betaine improves metabolic measures, liver fat and/or endothelial function in humans with glucose intolerance who are overweight.

Detailed description

This study is a single site, prospective, randomized (1:1), double masked, placebo controlled trial to assess metabolic effects of betaine compared to placebo on glycemia and insulin sensitivity, liver fat and endothelial function.

Conditions

• Obesity
• Dysglycemia

Interventions

Type	Name	Description
DRUG	Betaine	Betaine or placebo administered orally in divided doses over 12 weeks
DRUG	Placebo	Placebo administered orally in divided doses over 3 months

Timeline

• Start date: 2014-01-01
• Primary completion: 2017-12-01
• Completion: 2018-08-01
• First posted: 2013-09-25
• Last updated: 2021-04-20
• Results posted: 2021-04-20

Locations

1 site across 1 country: United States