NCT01949935

Efficacy Study of Mupirocin on Infection After Coronary Artery Bypass Grafting

MIR-CABG: A Randomized, Double-blind, Placebo-controlled, Single-Center Study to Evaluate the Impact of Mupirocin on Infection Rate Post Coronary Artery Bypass Grafting

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 974 (actual)
• Sponsor: Horizon Health Network · Academic / Other
• Sex: All
• Age: 19 Years
• Healthy volunteers: Not accepted

Summary

The hypothesis is that application of Mupirocin to the nose before and after coronary artery bypass grafting surgery will reduce the incidence of surgical site infections.

Detailed description

Mupirocin applied to the nares is effective in eradicating nasal carriage of Staphylococcus species. Abundant evidence has documented that a majority of gram positive surgical site infections share bacterial phenotypes identical with nasal phage types. Conflicting literature exists regarding the efficacy of mupirocin in reducing the incidence of surgical site infections. A randomized prospective double-blind placebo-controlled trial is needed to help settle this question in the setting of coronary artery bypass grafting surgery where surgical site infections carry significant morbidity, cost, and mortality.

Conditions

• Surgical Site Infections

Interventions

Type	Name	Description
DRUG	Mupirocin

Timeline

• Start date: 2009-03-01
• Primary completion: 2013-05-01
• Completion: 2013-05-01
• First posted: 2013-09-25
• Last updated: 2013-09-25

Locations

1 site across 1 country: Canada