NCT01948609

Prospective Research of Outcomes After Salpingo-oophorectomy

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 100 (actual)
• Sponsor: University of California, San Francisco · Academic / Other
• Sex: Female
• Age: 35 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

PROSper is a prospective cohort study of 100 women 35-50 years of age with BRCA 1/2 mutations who have elected to either undergo risk reducing salpingo-oophorectomy (RRSO) or nonsurgical management. The investigators will compare the change in cardiovascular health, bone health, sexual function, quality of life, and menopausal symptoms over 3 years of follow-up between women who undergo RRSO (baseline just prior to surgery) and age-matched controls that do not undergo RRSO. The investigators hypothesis is that women who undergo a premature surgical menopause induced by RRSO have worse cardiovascular health and bone health compared with women who do not undergo RRSO.

Conditions

• BRCA1 Gene Mutation
• BRCA2 Gene Mutation

Timeline

• Start date: 2014-07-01
• Primary completion: 2021-12-01
• Completion: 2021-12-01
• First posted: 2013-09-23
• Last updated: 2022-09-07

Locations

1 site across 1 country: United States