NCT01947673

Mechanisms of Intradialytic Hypertension

Sympathetic Regulation in Intradialytic Hypertension

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 49 (actual)
• Sponsor: Emory University · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Patients with end-stage renal disease (ESRD) are at significantly higher risk for death due to cardiovascular disease. Those with paradoxical increases in blood pressure (BP) during hemodialysis (HD), defined as intradialytic hypertension (IDH), are at even greater risk of cardiovascular mortality. This study seeks to determine the mechanisms that underlie IDH, and whether mindfulness meditation might improve BP during dialysis in these patients. The investigators will first determine if increased adrenaline levels during volume removal contributes to IDH. The investigators will then determine lack of suppression of adrenaline levels in the setting of a high BP also contributes to IDH. This will be done by manipulating blood pressure by using small amounts of vasoactive drugs, and determining if an appropriate response in adrenaline levels occurs. Lastly, the investigators will determine if an intradialytic mindfulness meditation program improves BP and adrenaline levels in ESRD patients with IDH.

Conditions

• Renal Failure Chronic Requiring Hemodialysis
• Haemodialysis-induced Symptom
• Hypertension

Interventions

Type	Name	Description
OTHER	Mindfulness Meditation
OTHER	Health Education

Timeline

• Start date: 2013-09-01
• Primary completion: 2017-11-01
• Completion: 2017-11-01
• First posted: 2013-09-20
• Last updated: 2021-07-15

Locations

1 site across 1 country: United States