NCT01947335

IVUS Guidance to Reduce Contrast in Coronary Angioplasty

Minimizing cOntrast utiliZAtion With IVUS Guidance in coRonary angioplasTy: The MOZART Study

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 83 (actual)
• Sponsor: InCor Heart Institute · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study tests the hypothesis that ultrasound-guided PCI reduces contrast volume during the procedure.

Detailed description

Contrast-induced acute kidney injury (CI-AKI) is an important adverse effect of percutaneous coronary interventions. Despite various efforts, very few preventive measures have been shown effective in reducing its incidence. The final volume of contrast media utilized during the procedure is a well-known independent factor affecting the occurrence of CI-AKI. Intravascular ultrasound (IVUS) has been largely used as an adjunctive diagnostic tool during percutaneous coronary intervention (PCI). When fully explored, IVUS provides precise information for guiding the PCI strategy. IVUS allows accurate vessel and lesion sizing, determination of plaque calcification (and the need for pre-stent plaque preparation), assessment of post-stent results (including edge dissections and residual lesion, as well as stent underexpansion or incomplete apposition). Therefore, IVUS has the potential to reduce the utilization of contrast media during PCI. In the present study, we hypothesize that IVUS guidance is associated with a significant reduction in the volume of contrast media during PCI, in comparison to standard angiography-guided intervention.

Conditions

• Contrast Media Reaction
• Acute Renal Failure

Interventions

Type	Name	Description
DEVICE	IVUS-guided PCI	Intravascular ultrasound guided percutaneous coronary intervention

Timeline

• Start date: 2012-11-01
• Primary completion: 2013-09-01
• Completion: 2013-09-01
• First posted: 2013-09-20
• Last updated: 2016-06-15
• Results posted: 2016-06-15

Locations

1 site across 1 country: Brazil