NCT01941576

Effects of rhBNP in Pediatrics After Corrective Repair of Tetralogy Of Fallot

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 120 (actual)
• Sponsor: Shanghai Jiao Tong University School of Medicine · Academic / Other
• Sex: All
• Age: 1 Month – 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine the effects of rhRNP on urine output and hemodynamics following corrective repair of Tetralogy Of Fallot.

Detailed description

CVP(central venous pressure) and cardiac output are serious index in children with Tetralogy Of Fallot after the corrective repair.The purpose of this study is to investigate if the therapy of rhRNP can improve the survival and life quality after the corrective repair of Tetralogy Of Fallot.

Conditions

• Congenital Heart Defects
• Tetralogy Of Fallot

Interventions

Type	Name	Description
DRUG	recombinant human brain natriuretic peptide (rhBNP)	Patients are first given a loading dose of recombinant human brain natriuretic peptide (rhBNP) 1.5 mcg/kg, followed by continuous infusion recombinant human brain natriuretic peptide 0.01-0.01mcg/kg/min for 72 hours.
DRUG	Placebo (0.9% sodium chloride)	Patients after corrective repair of Tetralogy Of Fallot will be treat with routinely therapy, including inotropics and diuretics, combined a placebo infusion 24 hours after operation.

Timeline

• Start date: 2013-09-01
• Primary completion: 2017-12-31
• Completion: 2019-07-20
• First posted: 2013-09-13
• Last updated: 2020-10-28

Locations

1 site across 1 country: China