NCT01940614

Use of Copeptin in Diabetes Insipidus

Use of Copeptin in the Differential Diagnosis of Diabetes insipidus-a Prospective International Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 156 (actual)
• Sponsor: University Hospital, Basel, Switzerland · Academic / Other
• Sex: All
• Age: 16 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Prospective evaluation of the novel biomarker copeptin in the differential diagnosis of diabetes insipidus against the standard diagnostic test methods.

Detailed description

Purpose of this study is to compare the overall diagnostic accuracy of the three following diagnostic test procedures in diabetes insipidus (central, nephrogenic) and primary polydipsia: a) classical water deprivation test alone, b) classical water deprivation test plus plasma copeptin cut-off levels, c) hypertonic saline infusion test plus plasma copeptin measurement. The investigators hypothesize that firstly b) and c) is better as a). Secondly the investigators hypothesize that c) is non-inferior to b).

Conditions

• Diabetes Insipidus
• Primary Polydipsia

Interventions

Type	Name	Description
OTHER	Water deprivation test	Classical water deprivation test alone
OTHER	Water deprivation test	classical water deprivation test plus plasma copeptin cut-off levels
OTHER	Hypertonic saline infusion	hypertonic saline infusion test plus plasma copeptin measurement

Timeline

• Start date: 2013-07-01
• Primary completion: 2017-06-01
• Completion: 2017-12-01
• First posted: 2013-09-12
• Last updated: 2018-04-17

Locations

1 site across 1 country: Switzerland