NCT01939626

Comparison of Human Embryo Development Using Sequential and Single Media With Time-lapse Imaging

Comparison of Human Embryonic Development Using Sequential and Single Media in IVF Monitored by Time-lapse Imaging.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 128 (actual)
• Sponsor: Vitrolife · Industry
• Sex: Female
• Age: 21 Years – 40 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to compare human embryo in vitro development in sequential and single-step culture medium using time-lapse imaging.

Detailed description

Objective: To study whether a culture medium that allows undisturbed culture supports human embryo development to the blastocyst stage equivalently to a well-established sequential media. Design: Randomized, double-blinded sibling trial. Setting: Independent in vitro fertilization (IVF) clinics. Patient(s): One hundred twenty-eight patients, with 1,356 zygotes randomized into two study arms. Intervention(s): Embryos from each patient were randomly allocated into two study arms to compare embryo development on a time-lapse system using a single-step medium or sequential media.

Conditions

• Infertility

Interventions

Type	Name	Description
DEVICE	Single-step medium	This medium will allow in vitro culture of human embryos for 5/6 days
DEVICE	Standard culture medium	This culture system needs media change on day 3 of culture.

Timeline

• Start date: 2013-09-01
• Primary completion: 2014-02-01
• Completion: 2014-02-01
• First posted: 2013-09-11
• Last updated: 2021-01-12

Locations

4 sites across 2 countries: United States, Sweden