NCT01938651

Ultra High Field MRI and MRS Techniques in Diagnosing Breast Cancer

Ultra-High Field (7 Tesla) MRI/MRS Evaluation of Breast Cancer

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 3 (actual)
• Sponsor: Vanderbilt-Ingram Cancer Center · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This pilot clinical trial studies ultra-high field magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) techniques in diagnosing breast cancer. New diagnostic procedures may be a more sensitive way to detect breast cancer.

Detailed description

PRIMARY OBJECTIVES: I. To implement quantitative dynamic contrast-enhanced (DCE)-MRI, diffusion-weighted (DW)-MRI, 31 phosphorus (31P) MRS, magnetization transfer (MT)-MRI, chemical exchange saturation transfer (CEST)-MRI, and high-resolution structural imaging at 7 Tesla in patients for diagnosing breast tumors. OUTLINE: Patients undergo measurement of tumor perfusion and permeability using DCE-MRI, tumor cellularity using DW-MRI, phospholipid metabolism using 31P MRS, macromolecular content using MT-MRI, and cellular protein content using CEST-MRI. Diagnostic performance of one, or a combination, of these metrics will be investigated in the context of breast cancer.

Conditions

• Breast Cancer

Interventions

Type	Name	Description
PROCEDURE	high field strength magnetic resonance imaging	Undergo 7T MRI
PROCEDURE	magnetic resonance spectroscopic imaging	Undergo 31P MRS
PROCEDURE	chemical exchange saturation transfer magnetic resonance imaging	Undergo CEST-MRI
PROCEDURE	diffusion-weighted magnetic resonance imaging	Undergo DW-MRI
PROCEDURE	dynamic contrast-enhanced magnetic resonance imaging	Undergo DCE-MRI

Timeline

• Start date: 2013-01-01
• Primary completion: 2015-06-01
• Completion: 2015-06-01
• First posted: 2013-09-10
• Last updated: 2016-08-03

Locations

1 site across 1 country: United States