NCT01935752

Pathophysiological Mechanisms of Fibromuscular Dysplasia

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 150 (actual)
• Sponsor: Assistance Publique - Hôpitaux de Paris · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

Fibromuscular dysplasia is an non inflammatory non atherosclerotic obstructive arterial disease affecting mid-size arteries. It is considered as a rare vascular disease of unknown origin. Fibromuscular dysplasia may become symptomatic depending on location and severity of narrowing of the arterial lumen. for example,when a stenosis develops within a renal artery, arterial hypertension may develop. The cause of fibromuscular dysplasia is unknown. Several factors have been suggested to be associated with it: tobacco abuse or oestrogens. In order to progress into identifying possible causative mechanisms of the disease, we design a pathophysiology study destined to assess endothelial function in patients with fibromuscular dysplasia and to identify possible plasmatic biomarkers of the disease.

Conditions

• Fibromuscular Dysplasia

Interventions

Type	Name	Description
OTHER	blood samples	blood samples
OTHER	vascular echotracking	endothelial function study and virtual histology study

Timeline

• Start date: 2011-11-01
• Primary completion: 2014-10-01
• Completion: 2014-10-01
• First posted: 2013-09-05
• Last updated: 2016-10-18

Locations

1 site across 1 country: France