NCT01933685

Study of Immune Responses Induced by a HIV Vaccine

Randomized, Double Blind Evaluation of Sequential Administration of gp120 B/E (AIDSVAX B/E) (GSID) With 1-Year Boosting in HIV-uninfected Thai Adults

• Status: Unknown
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: U.S. Army Medical Research and Development Command · Federal
• Sex: All
• Age: 20 Years – 40 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to define the immune responses induced by a HIV vaccine, AIDSVAX B/E. Blood and mucosal samples will be collected to assess immune responses.

Detailed description

The primary purpose of this study is to define in HIV-uninfected volunteers the innate, cell-mediated and humoral responses induced by AIDSVAX B/E in the systemic and mucosal compartments and to characterize B cell functional specificities in peripheral blood, bone marrow and sigmoid compartments.

Conditions

• HIV Infections

Interventions

Type	Name	Description
BIOLOGICAL	AIDSVAX B/E	1 mL per injection (300 ug dose/antigen for a total of 600 ug/dose administered)
BIOLOGICAL	AIDSVAX B/E Placebo	1 mL per injection

Timeline

• Start date: 2014-07-03
• Primary completion: 2016-05-24
• Completion: 2020-05-01
• First posted: 2013-09-02
• Last updated: 2019-09-19

Locations

1 site across 1 country: Thailand