NCT01932112

Adenosine Effect on Persistent Pulmonary Vein Isolation Line Evaluation (APPLE Trial)

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 378 (actual)
• Sponsor: Yong Seog Oh · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The investigators studied the effects of adenosine on the reconnection rate after successful pulmonary veins isolation by radiofrequency catheter ablation in patients with drug-resistant atrial fibrillation

Detailed description

Pulmonary vein isolation has emerged as an effective therapy for paroxysmal atrial fibrillation. However, atrial fibrillation recurs in up to 50% of patients, generally because of recovery of pulmonary vein conduction. Adenosine given during the initial procedure may reveal dormant pulmonary vein conduction, thereby identifying the need for additional ablation, leading to improved outcomes.

Conditions

• Atrial Fibrillation
• Persistent Common Pulmonary Vein

Interventions

Type	Name	Description
DRUG	Adenosine arm	After pulmonary vein isolation,20mg Intracardiac adenosine will be given to treatment group, will evaluate pulmonary vein reconnection.

Timeline

• Start date: 2012-11-01
• Primary completion: 2015-04-01
• Completion: 2015-05-01
• First posted: 2013-08-30
• Last updated: 2017-04-26
• Results posted: 2016-04-13

Locations

1 site across 1 country: South Korea