NCT01931709

FDG PET and DCE-MRI in Predicting Response to Treatment in Patients With Breast Cancer

Quantitative Dynamic PET and MRI and Breast Cancer Therapy

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 35 (actual)
• Sponsor: University of Washington · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This clinical trial studies fludeoxyglucose F 18 (FDG) positron emission tomography (PET) and dynamic contrast-enhanced (DCE)-magnetic resonance imaging (MRI) in predicting response to treatment in patients with breast cancer. Comparing results of diagnostic procedures done before, during, and after chemotherapy may help doctors predict a patient's response to treatment and help plan the best treatment.

Detailed description

PRIMARY OBJECTIVES: I. To determine whether detailed kinetic analysis of FDG PET and magnetic resonance (MR) imaging studies for measures of tumor metabolism and blood perfusion can predict response and outcome for breast cancer patients undergoing neo-adjuvant therapy. II. To compare the in vivo tumor biology associated with responsive and resistant tumors as measured by kinetic changes in FDG PET and MR imaging parameters to tumor subtypes analyzed from assay of pre-therapy biopsy and post-therapy surgical tissue. OUTLINE: Patients undergo FDG PET and DCE-MRI 1-2 weeks before prior to chemotherapy initiation, between 1-12 weeks after initiation of the first course of chemotherapy, and after the completion of chemotherapy (within 4 weeks prior to surgery).

Conditions

• Male Breast Cancer
• Stage II Breast Cancer
• Stage IIIA Breast Cancer
• Stage IIIB Breast Cancer

Interventions

Type	Name	Description
RADIATION	fludeoxyglucose F 18	Undergo FDG PET
DEVICE	positron emission tomography	Undergo FDG PET
DEVICE	dynamic contrast-enhanced magnetic resonance imaging	Undergo DCE-MRI
OTHER	laboratory biomarker analysis	Correlative studies

Timeline

• Start date: 2011-11-01
• Primary completion: 2016-02-01
• Completion: 2022-10-26
• First posted: 2013-08-29
• Last updated: 2023-11-18
• Results posted: 2017-06-14

Locations

1 site across 1 country: United States