NCT01931683

Dosing Study of Remifentanil for Smooth Removal of the Laryngeal Mask Airway (LMA)

Effect-site Concentration of Remifentanil for Smooth Removal of the LMA From Propofol Anesthesia

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 27 (actual)
• Sponsor: Ajou University School of Medicine · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

The investigators attempted to determine the optimal effect-site concentration of remifentanil for smooth removal of the LMA from propofol anesthesia.

Detailed description

At the end of the surgery, propofol infusion was stopped and remifentanil was titrated to predetermined (initial concentration 1.0 ng/ml for the first patient). LMA removal was performed when the patients opened their eyes and spontaneous respiration and adequate tidal volume and ventilatory frequency were confirmed.

Conditions

• Drug Usage

Interventions

Type	Name	Description
DRUG	remifentanil	The concentration of remifentanil was determined by modified Dixon's up-and-down method, starting from 1.0 ng/ml (0.2 ng/ml as a step size)
DEVICE	laryngeal mask airway (LMA)	LMA was removed when the patients opened their eyes, and spontaneous respiration and adequate tidal volume and ventilatory frequency were confirmed

Timeline

• Start date: 2013-10-01
• Primary completion: 2014-02-01
• Completion: 2014-02-01
• First posted: 2013-08-29
• Last updated: 2014-10-15

Locations

1 site across 1 country: South Korea