NCT01931072

Exercise-induced Changes in DNA-methylation

The Effect of Exercise on Maximal Aerobic Capacity, DNA-methylation and Gene Expression in Healthy Elderly Men

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 37 (actual)
• Sponsor: Norwegian University of Science and Technology · Academic / Other
• Sex: Male
• Age: 70 Years – 75 Years
• Healthy volunteers: Accepted

Summary

The purpose of the study was to investigate whether regular moderate- or high-intensity interval training can change the DNA methylation in a long-lasting state, and whether these changes affect the gene expression. In addition, the investigators will determine whether the intensity of the training could be an affecting factor of the possible DNA-methylation change as well. The null hypothesis was that no such exercise-induced changes occur.

Conditions

• Healthy

Interventions

Type	Name	Description
BEHAVIORAL	High-intensity interval training	Interval training 3 times a week for 8 weeks
BEHAVIORAL	Moderate training	Moderate training 3 times a week for 8 weeks

Timeline

• Start date: 2012-08-01
• Primary completion: 2012-12-01
• Completion: 2013-12-01
• First posted: 2013-08-29
• Last updated: 2019-05-20

Locations

1 site across 1 country: Norway