NCT01931059

Acute D2 Receptor Blockade Induced Neuronal Network Changes in Human Volunteers

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 11 (actual)
• Sponsor: Northwell Health · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

To detect the effect of second-generation antipsychotic drug on the neural activity.

Detailed description

To detect functional correlation changes in the brain with anti-psychotic drug administration as compared to placebo, and b.) to measure if these changes correlate with the plasma level of anti-psychotic, and c.) to evaluate if these changes correlate with drug induced symptoms and changes in cognitive function.

Conditions

• Imaging of the Brain and Antipsychotics
• Neuronal Network Changes

Interventions

Type	Name	Description
DRUG	Risperidone	We gave oral liquid of risperidone one time 1-2 mg depending on subject's weight.
OTHER	Placebo	We gave oral liquid without active risperidone (pt and provider were both double blinded)

Timeline

• Start date: 2013-07-01
• Primary completion: 2016-07-01
• Completion: 2016-07-01
• First posted: 2013-08-29
• Last updated: 2018-04-30
• Results posted: 2018-04-30

Locations

1 site across 1 country: United States