NCT01923948

Preoperative Pain Control in Liver Surgery Patients

A Randomized Placebo-Controlled Study of Whether Pre-operative Pregabalin 150 mg Will Improve Pain Control in Patients With Hepatocellular Carcinoma Undergoing Partial Hepatectomy

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: Eastern Hepatobiliary Surgery Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Pregabalin 150mg or placebo are administered 1 hour preoperatively in patients undergoing partial hepatectomy. Postoperatively, patients receive morphine as rescue analgesic. Morphine consumption in the first 48 hours is documented. Postoperative pain is measured by the visual analogue scale (VAS) score.

Detailed description

Methods: In this Randomized Controlled Trial, patients undergoing partial hepatectomy will be administered a single pre-operative dose of Pregabalin or a placebo. Primary endpoints are as follows: * Post-operative analgesic requirements * Post-operative VAS scale (rated 0-10) * Complications * Post-operative antiemetic requirement * Length of stay

Conditions

• Pain, Postoperative
• Hepatocellular Carcinoma

Interventions

Type	Name	Description
DRUG	Pregabalin	One 150 mg oral dose of Pregabalin given before surgery
DRUG	Placebo (for Pregabalin)	One oral dose of placebo given before surgery

Timeline

• Start date: 2013-05-01
• Primary completion: 2014-12-01
• Completion: 2014-12-01
• First posted: 2013-08-16
• Last updated: 2016-03-31

Locations

1 site across 1 country: China