NCT01920815

Bicuspid Valve Aortopathy Feasibility Study

Bicuspid Valve Aortopathy: Feasibility of a Comparative Effectiveness Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 500 (estimated)
• Sponsor: Oregon Health and Science University · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

In order to determine the effectiveness of medical therapy options to prevent enlargement of the aorta in patients with a bicuspid aortic valve, a randomized study will be planned. This feasibility study will gather accurate data on number needed to screen, changes in medication use over time, and variance of the intended study endpoint.

Detailed description

The study will consider all patients with a bicuspid aortic valve and 1) determine the number of patients needed to be screened for a clinical trial, based on patient eligibility percentages applying specific inclusion and exclusion criteria, 2) for those meeting these criteria, follow changes in and compliance with medical therapy over two years, and 3) in a limited subset of eligible patients, perform MRI at baseline and after 2 years to measure the change in aortic area over time.

Conditions

• Bicuspid Aortic Valve

Interventions

Type	Name	Description
OTHER	No interventions

Timeline

• Start date: 2013-07-01
• Primary completion: 2016-06-01
• Completion: 2017-10-04
• First posted: 2013-08-12
• Last updated: 2018-09-19

Locations

6 sites across 1 country: United States