NCT01918683

TACE With or Without SBRT as Bridging Therapy for Pre-transplant HCC Patients

A Pilot Trial of Transarterial Chemoembolization With or Without Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma Patients Awaiting Liver Transplantation

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: Abramson Cancer Center at Penn Medicine · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This trial is designed to be the initial prospective pilot investigation of the effectiveness of combined SBRT and TACE as bridging therapy for HCC patients awaiting liver transplanation. No prospective clinical trials regarding the combination of TACE and SBRT in pre-transplant population have been performed. We propose the trial be conducted as a pilot clinical trial with the goal of enrolling 40 patients into each arm

Detailed description

The purpose of this study is to determine whether the combination of stereotatic body radiotherapy (SBRT) tand transarterial chemoembolization (TACE) is an effective "bridging therapy" for patients hepatocellular carcinoma (HCC) of the liver awaiting transplantation.

Conditions

• Hepatocellular Carcinoma

Interventions

Type	Name	Description
RADIATION	TACE transarterial chemoembolization
RADIATION	stereotatic body radiotherapy (SBRT)

Timeline

• Start date: 2013-07-01
• Primary completion: 2026-12-01
• Completion: 2027-12-01
• First posted: 2013-08-08
• Last updated: 2026-01-29

Locations

3 sites across 1 country: United States