NCT01918566

The Role of Endogenous GLP-1 (Glycolipoprotein) in Regulating Glucose Stimulated Brain Activity

The Role of Endogenous GLP-1 in Regulating Glucose Stimulated Brain Activity

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 12 (actual)
• Sponsor: University Hospital, Basel, Switzerland · Academic / Other
• Sex: Male
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

Our objective is to investigate neuro-anatomical correlates of the regulation of energy intake by means of functional MRI. Administration of glucose with and without lactisole and exendin as well as fructose is followed by functional brain MRI, and findings are correlated with serum GLP-1 levels as an endogenous satiety signal in humans.

Conditions

• Exploratory Behavior

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	tap water
DIETARY_SUPPLEMENT	Single intragastric instillation of 75g Glucose in 300ml tap water via nasogastric tube
DIETARY_SUPPLEMENT	Single intragastric instillation of 75g Glucose in 300ml tap water with 450ppm lactisole
DIETARY_SUPPLEMENT	25g Fructose in 300ml tap water
DIETARY_SUPPLEMENT	75g glucose in 300ml tap water with 600pmol/kg/min exendin 9-39
DIETARY_SUPPLEMENT	300ml tap water with 450ppm lactisole

Timeline

• Start date: 2012-03-01
• Primary completion: 2013-03-01
• Completion: 2013-03-01
• First posted: 2013-08-07
• Last updated: 2013-08-07

Locations

1 site across 1 country: Switzerland