NCT01917890

Radiosensitizing and Radioprotectve Effects of Curcumin in Prostate Cancer

Radiation Therapy With or Without Curcumin Supplement in Treating Patients With Prostate Cancer

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: Shahid Beheshti University of Medical Sciences · Academic / Other
• Sex: Male
• Age: 50 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Prostate cancer is the second most incident cancer among male population worldwide. Radiation therapy by itself or along with surgery and chemotherapy are the main treatments for prostate cancer however prostate cancer cells are only modestly responsive or even unresponsive to the cytotoxic effects of radiotherapy. Recently some in vitro and in vivo studies showed radiosensitizing and radioprotective effects for curcumin. No clinical trial has been done in this area and it is not yet known whether radiation therapy is more effective with or without curcumin supplements in treating patients with prostate cancer.

Conditions

• Prostate Cancer
• Radiation Therapy

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Curcumin	Patients undergo 74 Gy of intensity-modulated radiotherapy 5 times a week for 7-8 weeks. Patients take 3 grams of BCM95 Curcumin (as 6 × 500 mg capsules)
DIETARY_SUPPLEMENT	Placebo	Patients undergo 74 Gy of intensity-modulated radiotherapy 5 times a week for 7-8 weeks. Patients take 3 grams of roasted rice powder (as 6 × 500 mg capsules)

Timeline

• Start date: 2011-03-01
• Primary completion: 2013-10-01
• Completion: 2013-10-01
• First posted: 2013-08-07
• Last updated: 2015-11-18

Locations

1 site across 1 country: Iran