NCT01916642

A Dose-response Study of Lidocaine and Etomidate

Can Intravenous Lidocaine Decrease the Minimal Inducing Dose of Etomidate?: A Randomized Placebo-controlled Dose-response Study.

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 100 (actual)
• Sponsor: West China Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

IV lidocaine administration can reduce the minimal amount of Etomidate and time for induction of anesthesia.

Detailed description

The study was carried out in West China Hospital of Sichuan University, Chengdu, China. All the patients were informed in detail about the procedure and the medications they are going to get. Patients are well informed about the beneficial and possible hazards of the medicines and procedure. Patients are also informed that they can withdraw from the study at any time if they find it uncomfortable or harmful for them. Patients' written informed consent was obtained and registered for the permission from the Hospital's Ethics Board.

Conditions

• Etomidate Overdose of Undetermined Intent

Interventions

Type	Name	Description
DRUG	Lidocaine 1mg/kg	The total dosage of Etomidate needed for induction of anesthesia is recorded at last.
DRUG	Lidocaine 1.5mg/kg	same as other
DRUG	Lidocaine 2mg/kg	same as other
DRUG	Lidocaine 2.5mg/kg	same as other

Timeline

• Start date: 2013-04-01
• Primary completion: 2013-06-01
• Completion: 2013-07-01
• First posted: 2013-08-05
• Last updated: 2013-08-05