NCT01916512

Relationship Between CETP Deficiency and Atherosclerosis in Patients With Hyperalphalipoproteinemia

Investigation of Relationship Between Cholesteryl Ester Transfer Protein Deficiency and Carotid/Coronary Atherosclerosis in Patients With Hyperalphalipoproteinemia

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 1,500 (estimated)
• Sponsor: Osaka University · Academic / Other
• Sex: All
• Age: 40 Years – 100 Years
• Healthy volunteers: Accepted

Summary

The aim of this study is to determine whether high high density lipoprotein-cholesterol(HDL-C) level and low Cholesteryl Ester Transfer Protein(CETP) activity is atherogenic or not in subjects who received health checkups. We investigate the association between CETP activities and the severity of atherosclerosis assessed by intima-media thickness (IMT) and compare the atherogenic change between in subjects with high HDL-C level, low HDL-C level, high CETP activities and low CETP activities by examining the morbidity rate of atherogenic diseases, the rate of ischemic electrocardiography(ECG) change, Calc Score of artery from chest X-ray, Ankle Brachial Index/Pulse Wave Velocity and various serum atherogenic markers. And we also examine the correlation between normal lipid profile and concentration, activity and function of surface lipoprotein in subjects with variety of lipoprotein levels, including patients with hyper-LDL-cholesterolemia, hyper-HDL-cholesterolemia with low or no CETP activity, patients with high level of remnant cholesterol or hyperlipoproteinemia of apolipoprotein(Apo)B-48.

Conditions

• Low CETP Activity
• CETP Deficiency
• Hyperalphalipoproteinemia
• Hyper-LDL-cholesterolemia
• High Level of Remnant Cholesterol

Timeline

• Start date: 2012-02-01
• Primary completion: 2016-03-01
• First posted: 2013-08-05
• Last updated: 2015-04-15

Locations

1 site across 1 country: Japan