NCT01915446

Kidney and Intestinal Markers for Early Detection of Organ Injury After Endovascular Aortic Repair

Kidney and Intestinal Markers for Early Detection of Organ Injury After Endovascular Aortic Repair - The KISMED Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 20 (actual)
• Sponsor: University Hospital Regensburg · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study aims to investigate the predictive value of novel biomarkers and contrast-enhanced ultrasonography for early detection of abdominal end-organ (kidney and intestinum) hypoperfusion and ischemia in patients undergoing endovascular aortic repair (EVAR) for aortic aneurysm or dissection. In this context, patients will be monitored for renal biomarkers (TIMP-2, IGFBP7) and intestinal biomarkers (plasmatic intestinal fatty acid binding protein (i-FABP)) and local tissue perfusion will be assessed using contrast-enhanced ultrasonography (CEUS). The ultimate goal of this study is an early identification of patients developing one or both of these complications, which may facilitate a timely intervention to improve outcome.

Conditions

• Ischemia
• Fatty Acid-Binding Proteins
• Mesenteric Vascular Disease
• Acute Kidney Injury

Timeline

• Start date: 2013-07-01
• Primary completion: 2014-11-01
• Completion: 2014-11-01
• First posted: 2013-08-05
• Last updated: 2014-12-18

Locations

1 site across 1 country: Germany