NCT01913886

Mesenchymal Stem Cells to Treat Ischemic Cardiomyopathy

Autologous Grafting of Mesenchymal Stem Cells in Severe Refractory Ischemic Cardiomyopathy

• Status: Completed
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 10 (actual)
• Sponsor: Alexandra Cristina Senegaglia · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

This study will evaluate the safety and efficacy of intracoronary injection of mesenchymal stem cells (MSCs) to repair heart function in patients with myocardial ischemia.

Detailed description

Ischemic heart disease is a major public health problem in the industrialized and developing world. Current research is focusing on the development of cell-based therapies using stem cells to treat heart failure. Mesenchymal stem cells (MSCs) can differentiate into endothelial cells and participate in the development of new blood vessels in the heart damaged. Therefore, MSCs has shown promise for heart repair. The investigators study will evaluate the safety and efficacy of intracoronary injection of mesenchymal stem cells (MSCs) to repair heart function in patients with myocardial ischemia.

Conditions

• Ischemic Cardiomyopathy

Interventions

Type	Name	Description
PROCEDURE	MSCs injection	MSCs cells will be injected in two aliquots of 10 ml by catheterism

Timeline

• Start date: 2010-01-01
• Primary completion: 2013-09-01
• Completion: 2016-03-01
• First posted: 2013-08-01
• Last updated: 2017-12-13

Locations

1 site across 1 country: Brazil