NCT01908309

Contrast-inDuced nephRotoxicity as Assessed by the KIdney Load-to-DAmage RElationship

Contrast-inDuced nephRotoxicity as Assessed by the Cystatin-modified KIdney Load-to-DAmage RElationship

• Status: Completed
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 150 (actual)
• Sponsor: Azienda Sanitaria Locale 9, Grosseto · Other Government
• Sex: All
• Age: 20 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

We previously demonstrated that the slope of the relationship plotting individual iodine loads against contrast-induced serum creatinine changes ( the load-to-damage relationship, LDR) characterizes the intrinsic nephrotoxicity of the contrast. Aim of the present study is to compare, through the assessment of the LDR slope, the intrinsic nephrotoxicity of two different contrast media using serum cystatin-C changes as the LDR dependent variable.

Detailed description

We previously demonstrated that the slope of the relationship plotting individual iodine loads against contrast-induced serum creatinine changes ( the load-to-damage relationship, LDR) characterizes the intrinsic nephrotoxicity of the contrast and it may allow for reliable comparative evaluations among small sized study groups randomized to different contrast media. The aim of the present study is to compare, through the assessment of the LDR slope, the intrinsic nephrotoxicity of two different contrast media using serum cystatin-C changes as the LDR dependent variable.

Conditions

• Contrast Induced Acute Kidney Injury

Interventions

Type	Name	Description
DRUG	Iobitridol 350
DRUG	Iodixanol 320

Timeline

• Start date: 2013-04-01
• Primary completion: 2014-10-01
• Completion: 2014-10-01
• First posted: 2013-07-25
• Last updated: 2015-06-23

Locations

1 site across 1 country: Italy