NCT01905566

Comparison of Clopidogrel Versus Ticagrelor Therapy for Atherosclerotic Plaque Inflammation

Comparison of Clopidogrel Versus Ticagrelor Therapy for Atherosclerotic Plaque Inflammation: Serial FDG PET/CT Imaging Study of Carotid Artery and Ascending Aorta

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 50 (actual)
• Sponsor: CHEOL WHAN LEE, M.D., Ph.D · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Objectives: To compare the effects of clopidogrel versus ticagrelor on atherosclerotic plaque inflammation using serial FDG PET/CT imaging of carotid artery and ascending aorta. Hypothesis: Thrombosis and inflammation are tightly linked rather than separate entities. Therefore, P2Y12 receptor inhibitors may have an anti-ischemic effect by inhibiting plaque inflammation, and ticagrelor may be superior in efficacy to clopidogrel.

Conditions

• Plaque, Atherosclerotic

Interventions

Type	Name	Description
DRUG	Clopidogrel	75mg once a day
DRUG	Ticagrelor	90mg twice a day

Timeline

• Start date: 2013-09-01
• Primary completion: 2015-07-01
• Completion: 2015-08-01
• First posted: 2013-07-23
• Last updated: 2016-02-26

Locations

1 site across 1 country: South Korea