Trials / Completed
CompletedNCT01905501
Sevoflurane Protective Effect on Ischemia-reperfusion Injury. Multicenter, Randomized Controlled Trial
Sevoflurane Protective Effect on Ischemia-reperfusion Injury in Patients Undergoing Reconstructive Plastic Surgery With Microsurgical Flap. Multicenter, Randomized Controlled Trial.
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 132 (actual)
- Sponsor
- Regina Elena Cancer Institute · Academic / Other
- Sex
- Female
- Age
- 18 Years – 75 Years
- Healthy volunteers
- Not accepted
Summary
This study aimed to evaluate the possible protective effect of anesthetic technique balanced(with sevoflurane) compared with total intravenous anesthetic technique (propofol,remifentanil). The hypothesis is that the Sevoflurane may exert protective effect in regard to the ischemia-reperfusion injury induced on the microsurgical breast free flap during transfer to receiving area. The investigators will evaluate the continuous flap tissue oximetry and the level of biochemical markers.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Balanced anesthesia | Et-Sevo maIntained 1,8-2%, remifentanyl according target-controlled infusion maintained 1-3 ng/ml |
| DRUG | Total intravenous anesthesia | Propofol 3-4 µg/ml and remifentanyl 1-3 ng/ml according target-controlled infusion |
Timeline
- Start date
- 2013-02-01
- Primary completion
- 2014-09-01
- Completion
- 2015-02-01
- First posted
- 2013-07-23
- Last updated
- 2016-04-07
Locations
1 site across 1 country: Italy
Source: ClinicalTrials.gov record NCT01905501. Inclusion in this directory is not an endorsement.