NCT01903759

Kinetics of Inflammation Markers in Maternal Plasma: Study of the Correlation With the Diagnosis of Chorioamnionitis in Women Hospitalized for Spontaneous Rupture of the Fetal Membranes

Kinetics of Inflammation Markers in Maternal Plasma (Interleukins, Matrix Metalloproteinases -MMP): Study of the Correlation With the Diagnosis of Chorioamnionitis in Women Hospitalized for Spontaneous Rupture of the Fetal Membranes (SPROM) Before 34 Weeks of Amenorrhea (WA) With no Modification in the Usual Therapy.

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 97 (actual)
• Sponsor: Centre Hospitalier Universitaire Dijon · Academic / Other
• Sex: Female
• Age: 18 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

The principal aim of this study is to help obstetricians to diagnose chorioamniotic infection early, in cases of premature rupture of the fetal membranes before 34 WA, by proposing earlier and more specific markers of infection than FBC and CRP. The aim is to reduce vital and functional risk of acute chorioamnionitis for the mother, the fetus or the newborn,. If the kinetics profile of one or several markers correlates strongly with the diagnosis of chorioamnionitis, it could be used in clinical practice, possibly in the context of another clinical study. The results of the study presented here are destined to be published in obstetrics journals.

Conditions

• Patients With Spontaneous Rupture of the Fetal Membranes

Interventions

Type	Name	Description
OTHER	Blood samples

Timeline

• Start date: 2007-09-01
• Primary completion: 2010-05-01
• Completion: 2010-05-01
• First posted: 2013-07-19
• Last updated: 2013-07-19

Locations

1 site across 1 country: France