NCT01902810

Protective Effects of Propranolol in Adults

Protective Effects of Propranolol in Adults Following Major Burn Injury: A Safety and Efficacy Trial

• Status: Terminated
• Phase: Phase 2 / Phase 3
• Study type: Interventional
• Enrollment: 47 (actual)
• Sponsor: The University of Texas Medical Branch, Galveston · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This efficacy and safety trial will examine the effects and safety of propranolol administered to adult patients with severe burn injury. The investigators hypothesize that propranolol will provide significant benefit to adults following severe burn injury at doses that are safe and do not increase risk of adverse infectious and non-infectious outcomes.

Detailed description

A safety and efficacy trial is needed in order to determine the safety of propranolol treatment in adult burn patients, identify which subpopulations may be most likely to benefit from propranolol treatment and to identify propranolol dose levels that are not only safe but potentially effective.

Conditions

• Burn

Interventions

Type	Name	Description
DRUG	Propranolol	Propranolol by mouth given daily throughout hospitalization
DRUG	Placebo	Placebo by mouth given daily throughout hospitalization

Timeline

• Start date: 2013-07-01
• Primary completion: 2019-06-01
• Completion: 2019-07-12
• First posted: 2013-07-18
• Last updated: 2019-11-29

Locations

10 sites across 2 countries: United States, Canada