NCT01901861

Effect of the DPP-4 Inhibitor Sitagliptin on Islet Function After Mixed Meal in Patients With Type 2 Diabetes

Effect of a Single Dose of the DPP-4 Inhibitor on Islet Function After Igestion of a Standardized Mixed Meal in Subjects With Type 2 Diabetes

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 12 (actual)
• Sponsor: Lund University · Academic / Other
• Sex: Male
• Age: 20 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

study hypothesis to examine the acute effects on glycaemia and islet hormone secretion of increased levels of endogenous GLP-1 and GIP on islet cell function in men with type 2 diabetes. To this purpose, a standardized mixed meal test will be ingested with or without concomitant administration of sitagliptin (100mg).

Detailed description

In men subjects with type 2 diabetes treated with diet and exercise with or without metformin treatment as an antidiabetic agent, a standardized mixed meal test will be served with or without administration of sitagliptin (100mg).

Conditions

• Type 2 Diabetes

Interventions

Type	Name	Description
DRUG	Sitagliptin	Sitagliptin 100mg is given before meal ingestion
DRUG	Placebo	Placebo is given before meal ingestion

Timeline

• Start date: 2013-07-01
• Primary completion: 2015-12-01
• Completion: 2015-12-01
• First posted: 2013-07-17
• Last updated: 2015-12-15

Locations

1 site across 1 country: Sweden