NCT01900548

Effect of Intake of Whey Protein in Elderly Osteopenic Patients. Implications for Metabolism and Physical Function.

Effect of Intake of Protein High in Ketogenic Amino Acids (e.g. Leucine) in Elderly Osteopenic Patients. Implications for Muscle, Bone , Metabolism, and Physical Function.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 57 (actual)
• Sponsor: University of Aarhus · Academic / Other
• Sex: All
• Age: 60 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study is to investigate potential metabolic effects of whey protein high in protein and high in leucine(HPHL) compared to soy protein high in protein and low in leucine(HPLL) in osteopenic patients in a randomized controlled intervention study. The investigator hypothesize that HPHL will increase physical function and the ratio muscle mass / fat mass in this condition.

Detailed description

With an increase in the older population in Denmark and most other countries there is an increase in the rate of patients with age related bone and muscle weakness. Proteins with a high content in ketogenic amino acids e.g. leucine have been investigated in relation to these conditions. Generally acute studies in animals and some in human have been conducted and have demonstrated positive effects in relation to prevention and treatment of bone and muscle weakness. We want to investigate these tendencies with supplementation of proteins in a randomized, blinded, 4 month intervention study with three arms - 1) the control group. 2) soy protein(high protein, low leucine). 3) Whey protein(high protein, high leucine). To increase any possible effect of the supplementation the subjects will complete a resistance training program concurrently. The study will focus on the anabolic properties of the ketogenic amino acids in animal whey protein compared to vegetable soy protein. The investigator will study changes in: * Gait speed related to muscle strength * Walk distance in a Six-minute walk test related to sub maximal physical capacity * Body composition (LBM/FM ratio) by a DEXA-scanner * Biochemical markers on bone metabolism * Bone-mineral-density(BMD) and -content(BMC)(DEXA scans) * Muscle strength * Body balance * Protein and amino acid balance * Nitrogen balance * Gene-expression in muscle tissue * Biochemical markers on fat- sugar- and protein-metabolism * Biochemical markers on inflammation * Blood pressure * Insulin sensitivity by HOMA index * Estimated maximal physical capacity by a bicycle ergometer test. The perspective in this study is to develop a nutritional supplement with a high content of ketogenic amino acids (e.g. Leucine) that can be useful and beneficial in treatment and prevention of patients with bone and muscle weakness.

Conditions

• Osteopenia

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Whey protein (HPHL)	The Whey protein group are supplemented 45 gram of whey protein, high protein high leucine (HPHL), every day.
DIETARY_SUPPLEMENT	Soy protein (HPLL)	The Soy protein group are supplemented 45 gram of Soy protein, high protein low leucine (HPLL), every day.
DIETARY_SUPPLEMENT	Placebo (P)	Will not be given protein but the same energy content using maltodextrin (in a blended fashion).
OTHER	Resistance training	For 45 minutes 3 times a week the participants will complete resistance training with elastic bands in their own homes.

Timeline

• Start date: 2014-01-01
• Primary completion: 2015-12-01
• Completion: 2016-01-01
• First posted: 2013-07-16
• Last updated: 2017-04-07

Locations

1 site across 1 country: Denmark