NCT01895881

Estrogen Therapy as Prevention in the Progression of Aneurysm (EPPA) Trial

Estrogen Therapy as Prevention in the Progression of Aneurysm

• Status: Withdrawn
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: Rush University Medical Center · Academic / Other
• Sex: Female
• Age: 40 Years – 52 Years
• Healthy volunteers: Accepted

Summary

This study aims to determine if hormone replacement therapy, given during perimenopause may prevent the progression of saccular cerebral aneurysms.

Detailed description

This is a prospective, randomized, placebo-control trial to test the effect of estradiol in the prevention of progression of cerebral aneurysms. To evaluate the effect, each subject will be treated with either oral estradiol or placebo for 6 months. Subjects will be randomly assigned to 1 of 2 groups as follows: Double Blind Treatment Group Open-Label Regimen A1 1 mg Estradiol daily for 180 days B1 Placebo for 180 days Each group will be given oral Progesterone (3300 mg) for 10 days at the end of 90 days regardless of menstrual pattern. Subjects will be asked to keep a menstrual calendar throughout the trial. Serum markers will be drawn at baseline and every 90 days with the results blinded until the end of the trial. Magnetic resonance angiography (MRA) studies of the brain will be performed at month 6.

Conditions

• Cerebral Aneurysm
• Menopause
• Treatment

Interventions

Type	Name	Description
DRUG	Estradiol
DRUG	Placebo

Timeline

• Start date: 2013-04-01
• Primary completion: 2018-12-01
• Completion: 2018-12-01
• First posted: 2013-07-11
• Last updated: 2021-01-05

Locations

1 site across 1 country: United States