Trials / Completed
CompletedNCT01895699
The Effect of Contrast Agent on Endothelial Function in Healthy Men
- Status
- Completed
- Phase
- Phase 4
- Study type
- Interventional
- Enrollment
- 60 (actual)
- Sponsor
- Xiang Guang-da · Academic / Other
- Sex
- Male
- Age
- 20 Years – 30 Years
- Healthy volunteers
- Accepted
Summary
Contrast medium is essential for diagnosis of many diseases. However, recent studies showed that contrast agents can induce renal injury and is associated with poor long-term clinical outcome, especially in diabetes. To date, no data are available on the relationship between contrast medium and endothelial function. Endothelial dysfunction is known to precede atherosclerosis and is considered a risk marker for future development of cardiovascular disease. Therefore, we hypothesized that contrast agents may induce endothelial dysfunction in healthy men. In addition, we hypothesized that contrast induced endothelial dysfunction via free radicals. Thus, we also test alpha-lipoic acid whether or not protect endothelial dysfunction induced by contrast agents.
Conditions
- Contrast Agent
- Endothelial Function
- Cytokines
- Apoptosis of Endothelial Progenitor Cell
- Free Radical
- Alpha-lipoic Acid
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | Contrast agent |
Timeline
- Start date
- 2013-07-01
- Primary completion
- 2015-07-01
- Completion
- 2015-07-01
- First posted
- 2013-07-10
- Last updated
- 2015-08-13
Locations
1 site across 1 country: China
Source: ClinicalTrials.gov record NCT01895699. Inclusion in this directory is not an endorsement.