NCT01894191

Comparing the Adenoma Detection Rate With Air Insufflation, Water Immersion and Water Exchange

A Randomized, Controlled Trial Comparing the Adenoma Detection Rate With Air Insufflation, Water Immersion and Water Exchange During Colonoscopy

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 651 (actual)
• Sponsor: Dalin Tzu Chi General Hospital · Academic / Other
• Sex: All
• Age: 20 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Interval (missed) cancers and lower than expected mortality reduction of proximal colon cancers in the United States and elsewhere after screening colonoscopy drew attention to quality indicators. Missed adenomas which are more likely to be in the proximal colon may be contributing factors. An independent predictor of the risk of interval cancers is adenoma detection rate. In pilot observations, the investigators showed that water exchange enhanced adenoma detection in the right colon (cecum to hepatic flexure). This prospective, randomized controlled trial will compare water exchange with water immersion and traditional air insufflation in patients undergoing colonoscopy. The investigators test the hypothesis that compared with air insufflation and water immersion, water exchange produces a significantly higher adenoma detection rate in the right colon.

Detailed description

All of the procedures will be recorded and stored as digital files.

Conditions

• Adenoma

Interventions

Type	Name	Description
PROCEDURE	Air insufflation	Insufflation during colonoscopy including insertion phase
PROCEDURE	water immersion	Water will infused during insertion phase and removed during withdrawal phase of colonoscopy
PROCEDURE	Water exchange	Water will infused and removed during insertion phase of colonoscopy

Timeline

• Start date: 2013-05-01
• Primary completion: 2015-12-01
• Completion: 2015-12-01
• First posted: 2013-07-10
• Last updated: 2016-06-28

Locations

2 sites across 2 countries: United States, Taiwan