NCT01893489

Visualization of Carotid Atherosclerosis by 68Ga-MSA

Phase I Study to Evaluated the Safety of Noninvasive Molecular Imaging for the Detection of Inflammation in Carotid Atherosclerotic Lesions by Using Ga-68-NOTA-MSA in Healthy Volunteers and Patients With Coronary Artery Disease

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 12 (actual)
• Sponsor: Korea University · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Accepted

Summary

Until now, no specific atherosclerosis-targeting agent labeled with positron emitter is not yet available. Investigators developed neomannosyl human serum albumin(MSA) for the terminal mannose residues of MSA binding with the mannose receptors of macrophages in atherosclerosis, and investigators investigate whether 68Ga-MSA can be a novel agent for non-invasive molecular imaging of carotid atherosclerotic lesion in PET.

Conditions

• Atherosclerosis
• Carotid Atherosclerosis
• Noninvasive Imaging of Atherosclerosis

Interventions

Type	Name	Description
OTHER	68Gallium-MSA	68Gallium-MSA 2.0 mci for Positron Emission Tomogram(PET) imaging

Timeline

• Start date: 2012-09-01
• Primary completion: 2013-08-01
• Completion: 2013-08-01
• First posted: 2013-07-09
• Last updated: 2013-08-27

Locations

2 sites across 1 country: South Korea