NCT01892839

Increasing the Removal of Protein-Bound Solutes During Extended Hours Hemodialysis

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (estimated)
• Sponsor: Palo Alto Veterans Institute for Research · Academic / Other
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

Hemodialysis keeps patients with renal failure alive but does not restore normal health. Retention of chemicals that bind to plasma proteins and are therefore poorly removed by dialysis may contribute to ill health in patients receiving conventional treatment. This proposal will test the effect of a new method designed to improve the removal of protein-bound solutes during dialysis. The effects on blood chemical levels of two different dialysis prescriptions will be tested in patients already undergoing nocturnal in-center hemodialysis three times weekly.

Conditions

• End Stage Renal Failure on Dialysis

Interventions

Type	Name	Description
OTHER	low dialysate flow, smaller dialyzer	The subject will receive dialysis on the usual schedule and for the usual time but with a lower than usual dialysate flow and small dialyzer.
OTHER	high dialysate flow, larger dialyzer	The subject will receive dialysis on the usual schedule and for the usual time but with a higher than usual dialysate flow and large dialyzer.

Timeline

• Start date: 2013-07-01
• Primary completion: 2015-12-01
• Completion: 2016-12-01
• First posted: 2013-07-04
• Last updated: 2015-07-13

Locations

2 sites across 1 country: United States