NCT01892332

The Effective Concentration of Lidocaine With Fentanyl in Lumbar Epidural Anesthesia for Transurethral Resection of Prostate(TURP) in Elderly Patients

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Yonsei University · Academic / Other
• Sex: Male
• Age: 65 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

Epidural lidocaine is widely used in anesthesia for urologic or lower abdominal surgery because of its rapid onset. But the epidural anesthesia using high concentration of lidocaine may cause excessive motor block and unwanted side effects such as nausea, vomiting and hypotension. This is a study to determine the effective concentration of lidocaine with fentanyl in lumbar epidural anesthesia for transurethral resection of prostate in elderly patients.

Conditions

• BPH( Benign Prostate Hyperplasia)
• TURP(Transurethral Resection of Prostate)

Interventions

Type	Name	Description
DRUG	epidural block with lidocaine and fentanyl	The study method was a step-up/step-down sequence model where the dose for following patients was determined by the outcome of the preceding block. The starting concentration of lidocaine was 1.5 % mixed with fentanyl 75 ug. All patients receive 13mL of lidocaine with fentanyl 75ug. The concentration of lidocaine for subsequent patients is determined by the outcome in the previous patient according to up and down sequential allocation in 0.1% increments. In the case of block failure, the concentration of lidocaine was increased by 0.1%. Conversely, block success resulted in a reduction in concentration by 0.1%.

Timeline

• Start date: 2013-06-01
• Primary completion: 2014-01-01
• Completion: 2014-03-01
• First posted: 2013-07-04
• Last updated: 2014-07-28

Locations

1 site across 1 country: South Korea