NCT01891383

Clinical Characteristics of Dementias That Occur Remotely After Traumatic Brain Injury in Retired Military Personnel

Endophenotypes of Dementia Associated With Traumatic Brain Injury in Retired Military Personnel

• Status: Withdrawn
• Phase: —
• Study type: Observational
• Enrollment: 0 (actual)
• Sponsor: Uniformed Services University of the Health Sciences · Federal
• Sex: All
• Age: 50 Years – 95 Years
• Healthy volunteers: Accepted

Summary

The objective of this study is to measure the frequency and clinical types of mild cognitive impairment (MCI) or dementia that occur among up to 150 military retirees with and without a history of traumatic brain injury (TBI) among residents of the Armed Forces Retirement Home, Washington D.C. and the Veterans Home of California-Yountville. Investigators will compare the characteristics of dementia in those who have had a prior TBI to the characteristics in those without a history of TBI. It is our hypothesis that the dementia or MCI among those with prior TBI has distinct neuropsychological features that distinguishes it from those with dementia or MCI without a history of TBI.

Detailed description

75 participants with a history of TBI will be the cases (exposed) group. A control group of 75 retirement home residents without a history of TBI who are age-matched to the cases will also be recruited. Participants will be evaluated in a single visit, which will include neurological, psychiatric, and cognitive assessment. The evaluation will take approximately 4 hours. In some cases, the evaluation may be split into two 2 hour sessions.

Conditions

• Dementia
• Traumatic Brain Injury (TBI)
• Mild Cognitive Impairment (MCI)
• Chronic Traumatic Encephalopathy (CTE)
• Post-traumatic Stress Disorder (PTSD)

Timeline

• Start date: 2013-07-01
• Primary completion: 2016-06-01
• Completion: 2016-08-01
• First posted: 2013-07-03
• Last updated: 2019-01-18

Locations

2 sites across 1 country: United States