NCT01891292

Efficacy of Antioxidant Therapy Compared With Enalapril in Sickle Nephropathy

A Phase 2 Study of the Efficacy of Antioxidant Therapy Compared With Enalapril in Slowing the Progression of Sickle Nephropathy in Children

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: The University of The West Indies · Academic / Other
• Sex: All
• Age: 2 Years – 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine whether enalapril or antioxidant therapy (N-Acetylcysteine) is effective in reducing microalbuminuria in children with sickle cell disease and and its progression to sickle nephropathy

Conditions

• Microalbuminuria
• Sickle Cell Nephropathy

Interventions

Type	Name	Description
DRUG	Enalapril	0.25-0.35 mg/kg/day
DRUG	N-Acetylcysteine	N-Acetylcysteine 0.5 mmol/kg

Timeline

• Start date: 2013-07-01
• Primary completion: 2014-08-01
• Completion: 2015-09-01
• First posted: 2013-07-03
• Last updated: 2013-07-03

Locations

1 site across 1 country: Jamaica