NCT01888211

Effect of Omega 3 Fatty Acids on Vascular Function

Effect of Omega 3 Fatty Acid Supplementation on Endothelial Function, Endogenous Fibrinolysis and Platelet Activation in Patients With a Previous Myocardial Infarction

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: University of Edinburgh · Academic / Other
• Sex: Male
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The mechanisms through which omega-3 fatty acids reduce adverse cardiac events remain uncertain. The aim of the study was to investigate the effect of omega-3 fatty acid supplementation on endothelial vasomotor function, endogenous fibrinolysis, and platelet and monocyte activation in patients with coronary heart disease.

Detailed description

Twenty patients with a previous myocardial infarction were recruited into a randomised, double-blind, placebo-controlled, crossover trial of omega-3 fatty acid supplementation (2g/day for 6-weeks). Peripheral blood was taken for analysis of platelet and monocyte activation, and forearm blood flow was assessed in a subset of 12 patients during intrabrachial infusions of acetylcholine, substance P and sodium nitroprusside. Stimulated plasma tissue plasminogen activator (t-PA) concentrations were measured during substance P infusion.

Conditions

• Previous Myocardial Infarction

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Omega 3 fatty acid supplementation	2 grams Omacor daily
DIETARY_SUPPLEMENT	Olive Oil	2 grams olive oil daily

Timeline

• Start date: 2004-12-01
• Primary completion: 2006-06-01
• Completion: 2009-06-01
• First posted: 2013-06-27
• Last updated: 2024-05-01

Locations

1 site across 1 country: United Kingdom