NCT01887626

Study to Investigate if the Uptake of Ticagrelor Into the Body Differs Depending on Method of Administration.

An Open-label, Randomised, 3-period, 3-treatment, Crossover, Single-centre, Single-dose, Bioavailability Study With Alternative Methods of Administration of Crushed Ticagrelor Tablets, 90 mg, Compared to Whole Ticagrelor Tablets, 90 mg, in Healthy Volunteer

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 36 (actual)
• Sponsor: AstraZeneca · Industry
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

Study to investigate if the uptake of Ticagrelor into the body differs depending on method of administration.

Detailed description

Study to evaluate the bioavailability of the crushed ticagrelor tablets when administered orally or through nasogastric tubes compared to whole ticagrelor tablets given orally

Conditions

• Bioavailability Heathy Volunteers

Interventions

Type	Name	Description
DRUG	Ticagrelor 90 mg whole tablet	Ticagrelor 90 mg whole tablet administered as a single oral dose
DRUG	Ticagrelor 90 mg tablet crushed	Ticagrelor 90 mg crushed and suspended in water
DRUG	Dispersed ticagrelor 90 mg tablet suspended in water - nasogastric tube	Dispersed 90 mg ticagrelor 90 mg tablet suspended in water and administered through a nasogastric tube into the stomach

Timeline

• Start date: 2013-07-01
• Primary completion: 2013-09-01
• Completion: 2013-09-01
• First posted: 2013-06-27
• Last updated: 2013-09-18

Locations

1 site across 1 country: United Kingdom