NCT01885364

Esmolol Pretreatment on Pain During Injection of Propofol

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 120 (actual)
• Sponsor: Kyungpook National University Hospital · Academic / Other
• Sex: All
• Age: 19 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

Pain on injection of propofol is a common side effect. The present study was designed to investigate the effect of esmolol on pain on propofol injection and to compare it with remifentanil and placebo.

Detailed description

In a double-blind, prospective trial, 120 patients scheduled to undergo elective surgery were randomized to receive normal saline (n=30), remifentanil 0.35 μg/kg (n=30), esmolol 0.5 mg/kg (n=30), or Esmolol 1mg/kg (n=30) as pretreatment. Thirty seconds after pretreatment, 25% of the total calculated dose of propofol (2 mg/kg) was administrated into a dorsal hand vein. Ten seconds after propofol had been given at the rate of 0.5 ml/sec pain was assessed on a four-point scale (0=none, 1 = mild, 2= moderate, 3= severe).

Conditions

• Pain

Interventions

Type	Name	Description
DRUG	Normal saline	intravenous injection with normal saline before injection of propofol
DRUG	Esmolol	intravenous injection with remifentanil 0.5 mg/kg before injection of propofol
DRUG	Remifentanil	intravenous injection with remifentanil 0.35 ug/kg before injection of propofol
DRUG	propofol	intravenous injection after pretreatment

Timeline

• Start date: 2015-06-01
• Primary completion: 2015-11-01
• Completion: 2015-12-01
• First posted: 2013-06-25
• Last updated: 2016-02-08

Locations

1 site across 1 country: South Korea