NCT01883817

Effect of Omega-3 Fatty Acid on Cortical Function in ADHD

Docosahexaenoic Acid Augmentation of Cortical Attention Networks in ADHD

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: University of Cincinnati · Academic / Other
• Sex: All
• Age: 5 Years – 15 Years
• Healthy volunteers: Not accepted

Summary

The study hypothesis is that DHA is more effective than placebo in increasing brain activation and reducing symptoms in psychostimulant-free children with ADHD.

Detailed description

This study aims to determine the effects of 10-week dietary supplementation with the long-chain omega-3 fatty acid docosahexaenoic acid (DHA) or placebo on prefrontal cortical structural and functional connectivity using several neuroimaging techniques: DTI (Diffusion Tensor Imaging), 1H MRS(Proton Magnetic Resonance Spectroscopy), and fMRI (Functional Magnetic Resonance Imaging) in psychostimulant-free children with attention deficit hyperactivity disorder (ADHD). It is postulated that DHA supplements will increase brain activation and reduce ADHD symptomatology.

Conditions

• Attention Deficit Disorder

Interventions

Type	Name	Description
DRUG	DHA Omega-3	Patients will receive a fixed dose of DHA (1,200 mg/day, 600 mg twice daily) or placebo (corn/soy oil) over 10 weeks
DRUG	Placebo	corn/soy oil capsule with similar color, taste, and shape as experimental drug (DHA)

Timeline

• Start date: 2013-09-01
• Primary completion: 2017-03-03
• Completion: 2017-03-03
• First posted: 2013-06-21
• Last updated: 2022-03-16
• Results posted: 2022-03-16

Locations

1 site across 1 country: United States