NCT01883349

Cognitive Impairment and Imaging Correlates in End Stage Renal Disease

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 120 (actual)
• Sponsor: University of Kansas Medical Center · Academic / Other
• Sex: All
• Age: 30 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

This is an observational cohort to understand cognitive impairment in end stage renal disease before and after a kidney transplant.

Detailed description

Cognitive impairment is very common in patients with End Stage Renal Disease (ESRD). It exact mechanisms are not clear, but patients with ESRD have more cerebral white matter changes. Several studies have shown that cognitive function improves post-transplant, indicating that there may be some reversibility in the process. This study will examine the correlation between cognitive impairment and structural brain changes before and after renal transplantation. We will also study the correlation of cognitive function with serum inflammatory markers before and after transplant. These results will be compared to aged matched healthy controls without kidney disease.

Conditions

• End Stage Renal Disease

Interventions

Type	Name	Description
PROCEDURE	Kidney Transplant	Kidney Transplant Surgery
OTHER	No kidney transplant	The control group was made up of subjects without ESRD and were not on the renal transplantation waitlist.

Timeline

• Start date: 2013-03-01
• Primary completion: 2023-07-01
• Completion: 2023-09-01
• First posted: 2013-06-21
• Last updated: 2024-10-09

Locations

1 site across 1 country: United States