NCT01881347

Effects of Resveratrol on Endothelial Function in Type 2 Diabetes Mellitus

Randomized Crossover Study of The Effects of Resveratrol on Endothelial Function in Subjects With Type 2 Diabetes Mellitus

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 54 (actual)
• Sponsor: Boston University · Academic / Other
• Sex: All
• Age: 21 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The present study is designed to test the hypothesis that resveratrol supplementation will improve the function of the endothelium in patients with type 2 diabetes mellitus. The function of the endothelium will be tested with a non-invasive technique that uses ultrasound to measure the amount of dilation that occurs in the brachial artery following 5-minute cuff occlusion. To help us understand potential mechanisms of benefit, we will also collect blood, urine, and cell samples and test the effects of treatment on protein expression, nitric oxide production, and function of mitochondria.

Conditions

• Diabetes Mellitus

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Resveratrol	Resveratrol 100 mg daily for 2 weeks followed by resveratrol 300 mg daily for 2 weeks.
DIETARY_SUPPLEMENT	Placebo	Placebo 100 mg daily for 2 weeks followed by placebo 300 mg daily for 2 weeks.

Timeline

• Start date: 2013-01-01
• Primary completion: 2015-03-01
• Completion: 2016-07-01
• First posted: 2013-06-19
• Last updated: 2018-03-01

Locations

1 site across 1 country: United States