Trials / Completed
CompletedNCT01876303
Genetic Biomarkers in Saliva Samples From Patients With Ewing Sarcoma
Genetic Epidemiology of Ewing's Sarcoma
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 1,650 (estimated)
- Sponsor
- Children's Oncology Group · Network
- Sex
- All
- Age
- —
- Healthy volunteers
- Accepted
Summary
This clinical trial studies genetic biomarkers from saliva samples in patients with Ewing sarcoma. Studying samples of saliva from patients with cancer in the laboratory may help doctors learn more about changes that occur in deoxyribonucleic acid (DNA) and identify biomarkers related to cancer.
Detailed description
PRIMARY OBJECTIVES: I. To determine the association between the length of Ewing sarcoma breakpoint region 1-Friend leukemia virus integration 1 (EWS-FLI1) fusion protein binding sites (microsatellites) and risk of Ewing's sarcoma (ES). II. To determine the frequency and commonality of Caucasian ancestral markers in cases of ES self-identified as non-Caucasian (African-American, Asian, Hispanic). III. To determine the association between genomic variants in ES-related genes and hernia development (i.e. the integrin signaling pathway) and risk of ES. OUTLINE: Genomic DNA is extracted from participants' saliva samples and analyzed for expression of EWS-FLI1 and other ES-target genes.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | laboratory biomarker analysis | Correlative studies |
| OTHER | questionnaire administration | Ancillary studies |
Timeline
- Start date
- 2012-12-01
- Primary completion
- 2016-07-01
- First posted
- 2013-06-12
- Last updated
- 2016-07-14
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT01876303. Inclusion in this directory is not an endorsement.