NCT01873274

Comparative Study Menaquinone-7

Comparative Study of Three Delivery Systems of Menaquinone-7

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 107 (actual)
• Sponsor: Maastricht University Medical Center · Academic / Other
• Sex: All
• Age: 45 Years – 65 Years
• Healthy volunteers: Accepted

Summary

The objective of this study is to investigate the absorption of menaquinone-7 from a nutrient-enriched dairy product compared to a general dairy product enriched with menaquinone-7 and a menaquinone-7-containing supplement.

Detailed description

In an earlier study, beneficial effects of a nutrient-enriched dairy product on vitamin K-status were observed. The study product contained menaquinone-7 (MK-7) and omega-3 fatty acids for vascular health and extra minerals and antioxidants to support general health. It was the first time that such low dose of MK-7 (50 µg) could significantly improve vascular and general vitamin K-status already after short-term treatment. From the results of this study, it was assumed that the matrix of the dairy product and/or other components in the product, in which the vitamin was offered, contributed to optimal absorption and availability of vitamin K2. In this new study, the uptake and efficacy of MK-7 from the nutrient enriched product is investigated and compared to the uptake and efficacy from a MK-7-containing supplement and a basic dairy product enriched with MK-7.

Conditions

• Bioavailability

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	MK-7 containing capsule
DIETARY_SUPPLEMENT	basic yogurt enriched with MK-7
DIETARY_SUPPLEMENT	nutrient-enriched yogurt with MK-7

Timeline

• Start date: 2012-04-01
• Primary completion: 2012-10-01
• Completion: 2013-05-01
• First posted: 2013-06-10
• Last updated: 2013-06-13

Locations

1 site across 1 country: Netherlands