NCT01873170

Quantification of Immune Cells in Women Using Contraception (CHIC II)

Quantification of Immune Cells in Women Using Contraception

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 326 (actual)
• Sponsor: University of Pittsburgh · Academic / Other
• Sex: Female
• Age: 18 Years – 34 Years
• Healthy volunteers: Accepted

Summary

This study is being done to understand if using birth control causes changes in the immune cells within the reproductive tract (including the cervix and the lining of the uterus) of healthy women. Immune cells are important because they help prevent infections from starting and help fight infections that have started. Immune cells are also the type of cells that HIV (human immunodeficiency virus) infects so understanding more about them will help to better understand how to prevent the spread of HIV. Immune cells will be studied from the reproductive tract of women who want to start using one of the following contraceptives: an oral contraceptive pill (COC), Depo-Provera (DMPA), the levonorgestrel IUD (Mirena®), the copper IUD (ParaGard®), or the etonogestrel subdermal implant (Nexplanon®).Immune cells will also be studied from the reproductive tract of women who are not using birth control and who are not at risk of pregnancy for comparison.

Conditions

• HIV
• Immune Cells (Mucosal and Systemic)
• Contraception

Interventions

Type	Name	Description
DRUG	levonorgestrel exposure
DRUG	DMPA exposure
DRUG	etonogestrel exposure
DEVICE	IUD insertion
DEVICE	subdermal contraceptive implant insertion

Timeline

• Start date: 2013-08-01
• Primary completion: 2017-02-20
• Completion: 2020-10-01
• First posted: 2013-06-07
• Last updated: 2021-12-27

Locations

1 site across 1 country: United States