NCT01869907

Effect of Minocycline on Pain Caused by Nerve Damage

Effect of Minocycline on Neuropathic Pain

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Ziekenhuis Oost-Limburg · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine if minocycline is effective in the treatment of neuropathic pain. The effect of minocycline will be compared to the effect of placebo and amitriptyline.

Detailed description

Neuropathic pain is pain caused by damage to the central or peripheral nervous system. To date, therapy consists of tricyclic antidepressants (such as amitriptyline) or anticonvulsants. However, results are disappointing. Minocycline, a FDA-approved second generation tetracycline, was efficacious in various animal models of neuropathic pain. We want to study the effect of minocycline in neuropathic pain in humans. The type of neuropathic pain we want to investigate is lumbar radicular pain since this is the most prevalent condition associated with neuropathic pain in humans. This placebo-controlled randomized double blind trial consists of 3 arms: 1. Placebo, once daily by mouth during 14 days. 2. Amitriptyline 25mg, once daily by mouth during 14 days. 3. Minocycline 100mg, once daily by mouth during 14 days. Patients can take rescue medication if necessary: tramadol 50mg by mouths up to 3-times daily. Brain-derived neurotrophic factor is implicated in the generation and maintenance of neuropathic pain in different animal models of neuropathic pain. To study the role of brain-derived neurotrophic factor in neuropathic pain in humans, we will determine its concentration in serum and plasma before and after 14 days medication intake.

Conditions

• Neuropathic Pain Caused by Lumbar Radicular Pain

Interventions

Type	Name	Description
DRUG	Minocycline	100 mg once daily by mouth during 14 days
DRUG	placebo	once daily by mouth during 14 days
DRUG	Amitriptyline	25mg once daily by mouth during 14 days

Timeline

• Start date: 2011-09-01
• Primary completion: 2014-08-01
• Completion: 2014-08-01
• First posted: 2013-06-05
• Last updated: 2015-01-27

Locations

1 site across 1 country: Belgium